Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Soil Ecosystem02:23

The Soil Ecosystem

17.3K
Plants obtain inorganic minerals and water from the soil, which acts as a natural medium for land plants. The composition and quality of soil depend not only on the chemical constituents but also on the presence of living organisms. In general, soils contain three major components:
17.3K
Quarrying of Stone01:15

Quarrying of Stone

855
Quarrying is the process of extracting stone from a quarry, where specialized techniques are employed to remove large blocks of stone safely and efficiently. This process can involve controlled explosions or more precision-oriented methods such as cutting and drilling.
One common method involves using a diamond belt saw to cut large blocks from the quarry face. These blocks can be about 50 feet long and 12 feet high. After the initial vertical cut, drilling is performed at the base of the...
855
Methods of Obtaining Topography01:25

Methods of Obtaining Topography

550
Topography involves measuring and mapping land elevations, natural features, and artificial structures to create accurate representations of the terrain. Topographic surveying relies on traditional and modern methods, each with distinct advantages and limitations.Traditional Surveying Methods:Transit stadia surveys and plane table surveys were widely used traditional surveying methods. These techniques relied on instruments like theodolites and stadia rods for measuring distances and angles,...
550
Porosity and Absorption of Aggregate01:20

Porosity and Absorption of Aggregate

1.0K
Aggregates contain pores of varying sizes; while some are completely enclosed within the particles, others open onto the surface, allowing water to penetrate. The porosity of aggregates is a major factor contributing to the overall porosity of concrete, given that aggregates constitute about three-quarters of concrete's volume.
When all pores in an aggregate are filled with water, the aggregate is considered saturated and surface-dry. If left in dry air, water will evaporate until the...
1.0K
Placing Concrete01:17

Placing Concrete

1.7K
The concrete is placed as close as possible to its final position to avoid segregation. The placed concrete is then fully compacted to expel the entrapped air, and the next layer of concrete is laid while the underlying layer is still in the plastic state. The rate at which concrete is placed and compacted is kept equal.
While placing concrete, care is taken to ensure that the concrete is laid in uniform layers, and hand shoveling and moving concrete using poker vibrators is avoided. Also,...
1.7K
Laying Concrete Masonry01:16

Laying Concrete Masonry

668
Constructing a concrete masonry wall involves a series of steps designed to ensure durability, stability, and alignment. The construction starts with preparing the base, which includes cleaning the area where the wall will be erected. The next step involves spreading mortar where the first row of concrete blocks will be laid, typically starting at a corner section to help define the wall's boundaries.
Mortar application focuses on the face shells of the blocks, the sides that face outward,...
668

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Derivation and characterization of ubiquitin-specific protease 18 inhibitors.

JCI insight·2026
Same author

Rad53 regulates RNase H1, which promotes DNA replication through sites of transcription-replication conflict.

Cell reports·2025
Same author

RNase H1 and Sen1 ensure that transient TERRA R-loops promote the repair of short telomeres.

EMBO reports·2025
Same author

CDK2 inhibition produces a persistent population of polyploid cancer cells.

JCI insight·2025
Same author

Divergent populations of HIV-infected naive and memory CD4+ T cell clones in children on antiretroviral therapy.

The Journal of clinical investigation·2025
Same author

Genome-wide conditional degron libraries for functional genomics.

The Journal of cell biology·2024

Related Experiment Video

Updated: May 1, 2026

JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning
09:23

JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning

Published on: March 21, 2025

1.8K

Breaking new ground: digging into TERRA function.

André Maicher1, Arianna Lockhart1, Brian Luke1

  • 1Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Deutsches Krebsforschungszentrum (DKFZ)-ZMBH Alliance, Heidelberg, Germany.

Biochimica Et Biophysica Acta
|April 5, 2014
PubMed
Summary
This summary is machine-generated.

Telomeric Repeat containing RNA (TERRA) is transcribed from telomeres and may regulate telomere length and cellular aging. Increased TERRA is observed in cancer cells and yeast survivors, suggesting its potential as a biomarker.

Keywords:
ALTRecombinationSurvivorTERRATelomeraseTelomere

More Related Videos

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells
09:13

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells

Published on: January 17, 2019

6.8K
Soil Lysimeter Excavation for Coupled Hydrological, Geochemical, and Microbiological Investigations
10:30

Soil Lysimeter Excavation for Coupled Hydrological, Geochemical, and Microbiological Investigations

Published on: September 11, 2016

10.3K

Related Experiment Videos

Last Updated: May 1, 2026

JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning
09:23

JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning

Published on: March 21, 2025

1.8K
Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells
09:13

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells

Published on: January 17, 2019

6.8K
Soil Lysimeter Excavation for Coupled Hydrological, Geochemical, and Microbiological Investigations
10:30

Soil Lysimeter Excavation for Coupled Hydrological, Geochemical, and Microbiological Investigations

Published on: September 11, 2016

10.3K

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Research

Background:

  • Telomeres, protective caps on chromosomes, possess heterochromatin marks but are transcribed into TERRA.
  • TERRA transcription is conserved across species, originating in subtelomeric regions and extending across telomeric repeats.
  • Elevated TERRA levels are found in yeast survivors and ALT-mediated cancer cells.

Purpose of the Study:

  • To review current findings on TERRA transcription, localization, and function.
  • To focus on TERRA's role in regulating telomere length and replicative senescence.
  • To discuss the implications of increased TERRA in yeast survivors and ALT cancer cells.

Main Methods:

  • Literature review of recent publications on TERRA.
  • Analysis of TERRA's involvement in telomere end protection and heterochromatin formation.
  • Examination of TERRA's regulatory role in telomere length and senescence.

Main Results:

  • TERRA is implicated in telomere end protection and establishing telomeric heterochromatin.
  • TERRA appears to regulate telomere length and the onset of replicative senescence.
  • TERRA is a potential biomarker and therapeutic target in oncology.

Conclusions:

  • TERRA plays a crucial role in telomere regulation and cellular aging.
  • TERRA's dysregulation in cancer and yeast survivors highlights its significance.
  • Further research into TERRA could yield novel anti-cancer strategies.