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Physiological aspects of the aging cardiovascular system.

T Bennett1, S M Gardiner

  • 1Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, England.

Journal of Cardiovascular Pharmacology
|January 1, 1988
PubMed
Summary

Evidence for common age-related cardiovascular changes is weak. Cross-sectional studies are limited by mortality bias and subclinical disease, questioning findings on baroreflex, sympathetic, and neurohumoral functions in aging.

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Area of Science:

  • Cardiovascular Physiology
  • Gerontology
  • Human Physiology

Background:

  • Cross-sectional studies dominate research on aging cardiovascular physiology.
  • These studies are susceptible to selective mortality and subclinical disease, potentially confounding results.
  • Established age-related cardiovascular changes require re-evaluation.

Purpose of the Study:

  • To critically assess the evidence for commonly accepted age-related changes in human cardiovascular physiology.
  • To identify limitations in existing research methodologies.
  • To question the validity of findings regarding baroreflex, sympathetic, and neurohumoral functions in aging.

Main Methods:

  • Literature review and critical analysis of existing studies on cardiovascular aging.

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  • Evaluation of methodological limitations in cross-sectional research.
  • Assessment of evidence for specific physiological changes.

    • Main Results:

    • Substantive evidence for widely accepted age-related cardiovascular changes is limited.
    • Selective mortality and subclinical disease significantly impact cross-sectional study outcomes.
    • Published data offers little support for concepts like baroreflex impairment or sympathetic hyperactivation with age.

    Conclusions:

    • The evidence supporting common age-related cardiovascular physiological changes is weak.
    • Methodological limitations of current research undermine established findings.
    • Further rigorous research is needed to accurately understand cardiovascular aging.