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Declining mortality in cerebral venous thrombosis: a systematic review
Jonathan M Coutinho1, Susanna M Zuurbier, Jan Stam
1From the Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands.
Stroke
|April 5, 2014
Summary
Mortality from cerebral venous thrombosis (CVT) has significantly decreased over time. This trend is linked to improved diagnostics, better treatments, and evolving risk factors for CVT patients.
Area of Science:
- Neurology
- Vascular Medicine
- Epidemiology
Background:
- Cerebral venous thrombosis (CVT) was historically associated with a poor prognosis.
- Recent observations suggest a more favorable outcome for CVT patients.
- The study investigates the temporal trends in CVT mortality.
Purpose of the Study:
- To systematically analyze the apparent decline in mortality rates for patients diagnosed with cerebral venous thrombosis (CVT).
- To identify factors contributing to changes in CVT prognosis over time.
Main Methods:
- Conducted a systematic literature review of MEDLINE and EMBASE databases.
- Included studies with at least 40 CVT patients reporting mortality data.
- Analyzed data from 74 studies encompassing 8829 patients from 1942 to 2012.
Main Results:
- A significant inverse correlation was found between the year of patient recruitment and mortality (r = -0.72, P<0.001).
- Mortality rates for CVT have declined substantially over the study period.
- Decreases in the frequency of focal neurological deficits and coma were also observed.
Conclusions:
- Demonstrates a clear downward trend in mortality for cerebral venous thrombosis patients over time.
- Potential contributing factors include advancements in treatment, changes in risk factors, and improved diagnostic capabilities leading to earlier detection of less severe cases.
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