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Plant-derived epigenetic modulators for cancer treatment and prevention

Michael Schnekenburger1, Mario Dicato1, Marc Diederich2

  • 1Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, 9, rue Edward Steichen, L-2540 Luxembourg, Luxembourg.

Biotechnology Advances
|April 5, 2014
PubMed

Insights

Epigenetic alterations are key drivers of cancer development. Plant-derived compounds show promise as anticancer agents by targeting these epigenetic changes.

Area of Science:

  • Oncology
  • Epigenetics
  • Pharmacology

Background:

  • Carcinogenesis is a multistep process involving genetic mutations and epigenetic alterations.
  • Epigenetic deregulation is a hallmark of cancer, affecting crucial cellular processes.
  • Epigenetic alterations are early events in cancer, making them targets for intervention.

Purpose of the Study:

  • To provide an overview of plant-derived compounds with anticancer properties.
  • To highlight compounds that interfere with the epigenetic machinery.
  • To explore the potential of epigenetically active agents in cancer therapy.

Main Methods:

  • Literature review of plant-derived compounds and their epigenetic mechanisms.
  • Analysis of studies demonstrating anticancer effects of these compounds.
  • Focus on compounds targeting epigenetic machinery in cancer.

Main Results:

  • Plant-derived compounds exhibit promising anticancer properties.
  • These compounds interfere with key epigenetic mechanisms.
  • Evidence suggests potential for chemoprevention and chemotherapy.

Conclusions:

  • Epigenetic modifications are crucial in cancer development and progression.
  • Plant-derived compounds offer a promising avenue for novel anticancer strategies.
  • Targeting epigenetic machinery with natural compounds warrants further investigation.
Keywords:
Cancer preventionCancer therapyCell deathClinical trialsEpigeneticsNatural compoundsProliferation

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