Correlation research of carotid arterial sclerosis and left ventricular diastolic function in hyperthyroidism

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J Fang1, C Kang, Z Li

  • 1Department of Ultrasound Shanxi Academy of Medical Sciences & Shanxi DAYI Hospital, Taiyuan Shanxi Province, P. R. China - chunsongkangcn@163.com.

Minerva Cardioangiologica
|April 5, 2014
PubMed

Insights

Hyperthyroidism damages carotid artery and left ventricular diastolic function, but treatment improves these functions. Early carotid artery assessment aids in detecting cardiovascular disease in hyperthyroid patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Vascular Medicine

Background:

  • Hyperthyroidism is associated with cardiovascular complications.
  • Left ventricular diastolic dysfunction is a known complication of hyperthyroidism.
  • Carotid arterial sclerosis is a marker of systemic atherosclerosis.

Purpose of the Study:

  • To investigate the correlation between carotid arterial sclerosis and left ventricular diastolic function in patients with hyperthyroidism.
  • To assess the impact of I131 therapy on these parameters.

Main Methods:

  • Compared 70 newly-diagnosed hyperthyroid patients (32 post-treatment) with 74 healthy controls.
  • Utilized bilateral carotid ultrasound and echocardiography.
  • Measured carotid sclerosis index B, compliance coefficient (CC), pulse wave velocity (PWV), and left ventricular diastolic function parameters (E/A, e/a, E/e).

Main Results:

  • Pre-treatment: CC negatively correlated with E/e (r=-0.325, P<0.01); B and PWV positively correlated with E/e (r=0.270-0.297, P<0.05).
  • Post-treatment: CC negatively correlated with E/e (r=-0.462, P<0.01); B and PWV positively correlated with E/e (r=0.479-0.513, P<0.01).
  • Both carotid artery and left ventricular diastolic function improved after treatment.

Conclusions:

  • Carotid artery function and left ventricular diastolic function are impaired in hyperthyroidism and improve with treatment.
  • A significant correlation exists between carotid arterial sclerosis and left ventricular diastolic function in hyperthyroid patients.
  • Early detection of carotid artery changes may aid in identifying cardiovascular disease risk in hyperthyroidism.
Abstract

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