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Published on: March 18, 2015
Novel ruthenium(II) polypyridyl complexes as G-quadruplex stabilisers and telomerase inhibitors
Guoliang Liao1, Xiang Chen, Jingheng Wu
1MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, P. R. China. ceschh@mail.sysu.edu.cn.
Abstract:
Two novel ruthenium polypyridyl complexes, Ru[(bpy)2(pedppz)](2+) (1) and Ru[(bpy)2(pemitatp)](2+) (2) (bpy = 2'2-bipyridine, pdeppz = 10-(2-(piperidin-1-yl)ethoxy)dipyrido[3,2-a:2',3'-c]phenazine, pemitatp = 5-methoxy-1-(2-(piperidin-1-yl)ethyl)-isatino[1,2-b]-1,4,8,9-tetraazatriphenylene), bearing large planar π-delocalized aromatic systems with flexible chains have been synthesised and characterised. As expected, these complexes show inhibition towards telomerase by inducing and stabilising the G-quadruplex structure.
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