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Published on: November 15, 2024
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Significant association between interleukin-17A polymorphism and colorectal cancer
Inés Omrane1, Raja Marrakchi, Olfa Baroudi
1Laboratory of Human Genetics Immunology and Pathology, Faculty of Sciences Tunis, University of Tunis El Manar, El Manar, Tunis, 209, Tunisia, inesomrane@hotmail.fr.
Summary
The Interleukin (IL) 17A G197A polymorphism is linked to colorectal cancer susceptibility. Specifically, the IL17A GG genotype appears protective, while the A allele is associated with increased risk and advanced disease stages.
Area of Science:
- Immunogenetics
- Oncology
- Molecular Biology
Background:
- Interleukin (IL) 17A is a key inflammatory cytokine produced by Th 17 cells.
- IL-17A contributes to tissue inflammation by promoting the release of pro-inflammatory and neutrophil-mobilizing cytokines.
- Understanding genetic variations in IL-17A may elucidate colorectal cancer (CRC) pathogenesis.
Purpose of the Study:
- To investigate the association between the IL17A G197A polymorphism (rs2275913) and colorectal cancer risk.
- To analyze the relationship between IL17A G197A genotypes and clinical characteristics of CRC patients.
- To evaluate IL17A polymorphism as a potential biomarker for CRC location and progression.
Main Methods:
- Genotyping of the IL17A G197A polymorphism using a fluorescent-based restriction fragment length polymorphism method.
- Case-control study involving 102 CRC patients and 139 healthy controls.
- Statistical analysis to assess genotype frequencies, odds ratios (OR), and associations with clinical parameters.
Main Results:
- Significant differences in IL17A G197A genotype frequencies were observed between CRC patients and controls (p=0.001, OR=2.45).
- The IL17A GG genotype showed a protective effect against colon cancer (p=0.00001, OR=3.77).
- The A allele was associated with increased susceptibility, tumor localization, poorer differentiation, and advanced TNM stage in CRC patients (p<0.005 for all).
Conclusions:
- The IL17A G197A polymorphism is significantly associated with colorectal cancer risk.
- IL17A genetic variants correlate with key clinical features, including tumor location, differentiation, and stage.
- IL17A polymorphism may serve as a valuable biomarker for predicting CRC behavior and progression.
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