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Related Experiment Video

Updated: May 1, 2026

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Auditory hallucinations induced by trazodone.

Ippei Shiotsuki1, Takeshi Terao, Nobuyoshi Ishii

  • 1Oita University Faculty of Medicine, Oita, Japan.

BMJ Case Reports
|April 5, 2014
PubMed
Summary

Trazodone, an antidepressant, may cause auditory hallucinations in some patients. Discontinuing trazodone led to the complete resolution of hallucinations, suggesting a potential drug-induced side effect.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Neuroscience

Background:

  • Auditory hallucinations are a complex symptom often associated with psychiatric disorders.
  • Antidepressant medications are widely used but can have varied side effect profiles.

Observation:

  • A 26-year-old female experiencing a depressive state developed nocturnal auditory hallucinations.
  • These hallucinations were partially responsive to risperidone but initially resistant to blonanserin and paliperidone.

Findings:

  • Discontinuation of trazodone resulted in the complete resolution of auditory hallucinations.
  • Hallucinations did not recur even after subsequent dose reduction and discontinuation of risperidone.

Implications:

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  • Trazodone may be an iatrogenic cause of auditory hallucinations in susceptible individuals.
  • This case highlights the importance of considering medication side effects in the differential diagnosis of psychiatric symptoms.