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Related Concept Videos

Peptic Ulcer01:27

Peptic Ulcer

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Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the...
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Peptic Ulcer Disease I: Introduction01:30

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Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
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Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

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Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
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Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

Peptic Ulcer Disease III: Clinical Manifestations and Complications

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Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant...
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Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

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Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
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Peptic Ulcer Disease II: Pathophysiology01:24

Peptic Ulcer Disease II: Pathophysiology

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Peptic ulcer disease develops when protective mechanisms of the gastrointestinal mucosa are overwhelmed by harmful factors, leading to localized erosions in the stomach or proximal duodenum. The main causes are Helicobacter pylori infection and chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs).Helicobacter pylori–Induced InjuryBacterial Adaptation and Colonization:H. pylori is a spiral, Gram-negative bacterium adapted to the acidic stomach. and transmitted through oral-oral or...
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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
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Localized Pemphigus Vegetans without Mucosal Involvement.

Vk Jain1, N Jindal1, S Imchen1

  • 1Department of Skin and VD, PGIMS, Rohtak, India.

Indian Journal of Dermatology
|April 5, 2014
PubMed
Summary
This summary is machine-generated.

Pemphigus vegetans, a rare pemphigus vulgaris variant, can present without mucosal lesions. This case highlights effective treatment with oral steroids for limited cutaneous pemphigus vegetans.

Keywords:
BreastHallopeau typepemphigus vegetanstinea

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Area of Science:

  • Dermatology
  • Autoimmune blistering diseases

Background:

  • Pemphigus vegetans is a rare, benign variant of pemphigus vulgaris.
  • It is characterized by warty vegetations, typically in intertriginous areas.
  • Mucosal involvement is common in pemphigus vulgaris but less frequently reported in pemphigus vegetans.

Purpose of the Study:

  • To report a rare case of pemphigus vegetans with limited cutaneous involvement and no mucosal lesions.
  • To discuss the diagnostic findings and treatment response in such cases.
  • To highlight the scarcity of literature on pemphigus vegetans presenting solely with cutaneous manifestations.

Main Methods:

  • Clinical presentation of a 62-year-old female patient with vegetative plaques on the breast and groin.
  • Histopathological examination of skin biopsy.
  • Direct immunofluorescence studies of the affected skin.
  • Assessment of treatment response to oral steroids.

Main Results:

  • The patient presented with erythematous, moist, vegetative plaques on the left breast and left groin.
  • No oral or other mucosal surfaces were involved.
  • Histopathology and direct immunofluorescence confirmed pemphigus vegetans.
  • The patient achieved an excellent clinical response to oral steroid therapy.

Conclusions:

  • Pemphigus vegetans can manifest with limited cutaneous involvement without mucosal lesions.
  • Early diagnosis through histopathology and immunofluorescence is crucial.
  • Oral steroids appear effective in managing this rare variant of pemphigus vulgaris.