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Related Experiment Video

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Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure

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Published on: March 20, 2012

Teratogenicity with olanzapine.

Sathya Prakash¹, Rakesh Kumar Chadda¹

¹Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.

Indian Journal of Psychological Medicine

|April 5, 2014

Summary

This summary is machine-generated.

Second-generation antipsychotic olanzapine use in pregnancy may be linked to rare fetal developmental issues. Further research is needed to confirm the association between olanzapine and adverse pregnancy outcomes.

Keywords:

Olanzapine pregnancy teratogenicity

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Area of Science:

Obstetrics and Gynecology
Pharmacology
Teratology

Background:

Olanzapine, a second-generation antipsychotic, is widely used for managing psychiatric conditions.
It is classified as a Pregnancy Category C drug, with limited data on fetal toxicity.
The risk-benefit profile generally supports its use during pregnancy.

Observation:

A case report details a pregnancy exposed to olanzapine.
The fetus exhibited microcephaly and anophthalmos.

Findings:

The observed fetal abnormalities, microcephaly and anophthalmos, occurred in a pregnancy with olanzapine exposure.
A definitive causal link between olanzapine and these specific teratogenic effects remains unproven.

Implications:

This case highlights the need for cautious olanzapine prescription in pregnant individuals.
Larger-scale studies are warranted to investigate potential teratogenic effects of olanzapine.
Enhanced surveillance for fetal development in pregnancies exposed to second-generation antipsychotics is recommended.