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Effects of obstructive sleep apnea on cardiac function and clinical outcomes in Chinese patients with ST-elevation

Baoxin Liu1, Rong Guo1, Shunping Zhou1

  • 1Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai 200072, China.

Thescientificworldjournal
|April 5, 2014
PubMed

Insights

Obstructive sleep apnea (OSA) negatively impacts cardiac function and survival in ST-elevation myocardial infarction (STEMI) patients. OSA is an independent risk factor for major adverse cardiac events and cardiac mortality in this population.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Internal Medicine

Background:

  • Obstructive sleep apnea (OSA) is a common condition associated with cardiovascular disease.
  • ST-elevation myocardial infarction (STEMI) is a critical manifestation of coronary artery disease.

Purpose of the Study:

  • To investigate the effect of OSA on cardiac function in Chinese STEMI patients.
  • To determine the prognostic significance of OSA in STEMI patients.

Main Methods:

  • Retrospective analysis of 198 STEMI patients.
  • Doppler echocardiography to assess cardiac function.
  • Analysis of major adverse cardiac events (MACE) and cardiac mortality.

Main Results:

  • STEMI patients with OSA exhibited more hypertrophic myocardium and poorer cardiac function.
  • OSA group had significantly higher cumulative incidence of MACE and cardiac mortality over 24 months.
  • OSA was identified as an independent risk factor for MACE and cardiac mortality.

Conclusions:

  • OSA is a potent predictor of reduced survival in STEMI patients.
  • OSA exerts a detrimental prognostic impact on cardiac function and outcomes in STEMI.
Abstract

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