Molecular genetic approaches to Alzheimer's disease

Alzheimer's disease (AD) has emerged in the past decade as a major public health problem. Epidemiological and neuropathological studies have revealed AD to be a very frequent disease associated with aging. Already the fourth leading cause of death in the USA and consuming a major component of health care costs, AD will take on even greater importance with the continuous growth of the elderly population. A concerted effort has been made in recent years to attack AD using an arsenal of powerful molecular biological techniques, concentrating on two areas: the characterization of proteins implicated in the pathogenesis of AD and of the genes that encode them; and the use of genetic linkage to approach the primary defect in a familial form of AD (FAD). This review attempts to summarize and interpret the recent molecular, genetic and biochemical findings concerning the pathogenesis of AD.