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Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
Published on: October 2, 2016
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Recent advances in forensic drug analysis by DART-MS
Ashton D Lesiak1, Jason Re Shepard
1Department of Chemistry, University at Albany, State University of New York, 1400 Washington Ave., Albany, NY 12222, USA.
Bioanalysis
|April 8, 2014
Summary
Direct analysis in real-time mass spectrometry offers an advanced forensic tool. This technique enables rapid, direct sample analysis, improving forensic drug chemistry investigations.
Area of Science:
- Forensic Science
- Analytical Chemistry
- Mass Spectrometry
Background:
- Mass spectrometry is crucial in forensic science.
- Gas chromatography-mass spectrometry is a standard method.
- Emerging mass spectrometry techniques offer improvements.
Purpose of the Study:
- To review advanced mass spectrometry techniques for forensic applications.
- To focus on Direct Analysis in Real-Time Time-of-Flight Mass Spectrometry (DART-TOF-MS).
- To highlight applications in forensic drug chemistry.
Main Methods:
- Direct Analysis in Real-Time (DART) mass spectrometry.
- Ambient ionization technique for direct sample analysis.
- Time-of-Flight (TOF) mass analysis.
Main Results:
- DART-MS allows direct testing of gas, liquid, and solid samples.
- No sample preparation or extraction is required.
- Improved versatility and adaptability of mass spectrometry instrumentation.
Conclusions:
- DART-TOF-MS is a valuable tool for forensic science.
- The technique enhances analysis and characterization in forensic drug chemistry.
- Advanced mass spectrometry methods address emerging forensic issues.
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