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Fractures: Bone Repair

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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Related Experiment Video

Updated: May 1, 2026

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Published on: December 30, 2025

Defect healing with various bone substitutes.

Ian Yip¹, Li Ma, Nikos Mattheos

¹Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong, Hong Kong.

Clinical Oral Implants Research

|April 8, 2014

Summary

This summary is machine-generated.

Biphasic calcium phosphates (BCPs) showed comparable bone regeneration to deproteinized bovine bone mineral (DBBM) after six months. Granular BCPs initially outperformed DBBM, but moldable BCP with polylactide may impede osteogenesis.

Keywords:

animal study biomaterials bone substitutes

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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Area of Science:

Biomaterials Science
Regenerative Medicine
Orthopedic Surgery

Background:

Biphasic calcium phosphates (BCPs), a composite of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), are utilized as synthetic bone graft substitutes.
Their application is expanding in implant and periodontal surgeries for bone regeneration.
Evaluating BCPs against established bone graft materials like deproteinized bovine bone mineral (DBBM) is crucial for clinical efficacy.

Purpose of the Study:

To compare the bone regeneration rates and amounts in defects treated with three distinct BCP formulations versus DBBM.
To assess the influence of BCP composition and form on new bone formation over time.

Main Methods:

A critical-sized defect model was created in ten rabbits, with defects filled with BCP (60/40 HA/β-TCP), BCP (10/90 HA/β-TCP), moldable BCP (with polylactide), or DBBM.
Animals were euthanized at 3 and 6 months post-surgery for histological and histomorphometric analysis.
Quantification included mineralized new bone, bone marrow, residual graft material, and soft tissue percentages.

Main Results:

Mineralized new bone percentages were similar across all tested bone substitutes at both 3 and 6 months.
Significant increases in mineralized new bone were observed from 3 to 6 months for moldable BCP and DBBM, but not for the granular BCPs.
Residual graft material was higher in moldable BCP compared to granular BCP (60/40 HA/β-TCP) at 3 months.

Conclusions:

Granular BCP formulations demonstrated superior bone regeneration compared to DBBM at the 3-month time point.
All tested bone graft materials exhibited similar regenerative performance by 6 months.
The incorporation of polylactide into moldable BCP may potentially decelerate osteogenesis in grafted bone defects.