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Update on deep brain stimulation.

Robert H Howland

    Journal of Psychosocial Nursing and Mental Health Services
    |April 8, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Deep brain stimulation (DBS) is a safe and effective neurosurgical treatment for essential tremor, Parkinson's disease, and dystonia. Investigational uses for other conditions are ongoing, but require further research and FDA approval.

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    Area of Science:

    • Neurosurgery
    • Neurology
    • Therapeutic Brain Stimulation

    Background:

    • Deep brain stimulation (DBS) is an established neurosurgical therapy.
    • Current FDA-approved indications include essential tremor, Parkinson's disease, and primary dystonia.
    • DBS is also approved for treatment-resistant obsessive-compulsive disorder via Humanitarian Device Exemption.

    Purpose of the Study:

    • To review the current applications and investigational uses of DBS.
    • To highlight the safety and efficacy of DBS for approved neurological disorders.
    • To discuss the early-stage research into DBS for psychiatric conditions.

    Main Methods:

    • Review of existing literature on Deep Brain Stimulation.
    • Analysis of FDA-approved indications and investigational studies.
    • Summary of safety, tolerability, and efficacy data.

    Main Results:

    • DBS is safe, well-tolerated, and effective for essential tremor, Parkinson's disease, and dystonia.
    • Investigational DBS studies for epilepsy, obesity, chronic pain, and Tourette syndrome have not yet resulted in FDA approval.
    • Early-stage research is exploring DBS for severe chronic psychiatric disorders, warranting further investigation.

    Conclusions:

    • DBS is a proven therapy for specific movement disorders.
    • Expanded use of DBS requires further rigorous clinical investigation and regulatory approval.
    • The potential of DBS for psychiatric disorders is promising but in its nascent stages.