Related Experiment Video
Updated: May 1, 2026

09:14
An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
Published on: January 26, 2019
10.6K
Rotavirus vaccination in Central American children
Rolando Ulloa-Gutierrez1, María L Avila-Aguero
1Servicio de Infectología Pediátrica, Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera," Centro de Ciencias Médicas, PO Box 1654-1000, Avenida Paseo Colón, San José, Costa Rica.
Expert Review of Vaccines
|April 8, 2014
Summary
Rotavirus vaccines are reducing severe diarrhea in young children across Central America. This review examines the epidemiology and impact of widespread rotavirus vaccination programs in the region.
Area of Science:
- Pediatrics
- Vaccinology
- Infectious Diseases
Background:
- Rotavirus is a primary cause of severe diarrhea in children globally, with higher mortality in developing nations.
- Rotavirus vaccines (RV-1 and RV-5) are available in Central America, with widespread introduction into national immunization programs in several countries.
Discussion:
- This review synthesizes published data on rotavirus epidemiology and the effects of universal vaccination in Central America.
- It highlights the impact of rotavirus vaccination in countries like Guatemala, Honduras, El Salvador, Nicaragua, and Panama.
Key Insights:
- Rotavirus vaccination is a critical public health intervention for reducing childhood diarrhea and mortality.
- The widespread implementation of rotavirus vaccines in Central America shows promising public health benefits.
Outlook:
- Continued monitoring and research are essential to assess the long-term impact of rotavirus vaccination in Central America.
- Further data collection from countries with and without universal vaccination will inform regional and global strategies.
Related Concept Videos
Vaccinations
44.1K
Overview
44.1K
Bacterial Gastroenteritis
88
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
88
Vaccines
98
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...
98
Cytomegalovirus Disease
102
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102
Vaccine Production
144
Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
144
Drug Dosing: Infants and Children
1.0K
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
1.0K

