Antifertility activity of Artemisia vulgaris leaves on female Wistar rats
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Afsar Shaik1, Rupesh S Kanhere1, Rajaram Cuddapah1
1Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
Aim:
To evaluate the antifertility activity of Artemisia vulgaris leaves on female Wistar rats.
Method:
The plant extract was tested for its effect on implant formation at two dose levels, 300 and 600 mg·kg⁻¹, respectively. The effective methanolic plant extract was further studied for estrogenic potency on ovariectomised immature female Wistar rats.
Results:
The data presented in this study demonstrate the antifertility potential of Artemisia vulgaris methanolic leaf extract, which shows a strong and significant decrease in implant formation (100%), and a strong estrogenic effect resulting in a significant increase in uterine weight in immature ovariectomised rats. These observations suggest that the methanolic extract of Artemisia vulgaris leaves has strong anti-implantation activity and estrogenic activity.
Conclusion:
The methanolic plant extract of A. vulgaris has antifertility activity.
