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Metabolism goes viral

Shigeki J Miyake-Stoner1, Clodagh C O'Shea1

  • 1Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA.

Cell Metabolism
|April 8, 2014
PubMed

Insights

Adenovirus E4ORF1 activates MYC to promote a Warburg-like effect, reprogramming glucose metabolism for viral replication. This study reveals how viral proteins hijack cellular pathways to fuel pathological processes.

Area of Science:

  • Molecular Biology
  • Virology
  • Cancer Biology

Background:

  • Viral and cellular oncogenes reprogram host cell machinery for replication.
  • Oncogenes target protein interaction networks to alter cellular functions.

Purpose of the Study:

  • To investigate the mechanism by which adenovirus E4ORF1 interacts with MYC.
  • To understand how E4ORF1-induced MYC activation affects cellular metabolism.

Main Methods:

  • Analysis of adenovirus E4ORF1 protein.
  • Study of MYC glycolytic targets.
  • Investigation of cellular glucose metabolism.

Main Results:

  • Adenovirus E4ORF1 activates MYC's glycolytic targets.
  • This activation induces a Warburg-like metabolic effect.
  • Glucose is converted into nucleotides to support viral replication.

Conclusions:

  • Adenovirus E4ORF1 hijacks MYC to reprogram cellular metabolism.
  • The Warburg-like effect provides essential nucleotides for viral replication.
  • This highlights a convergence of viral and cellular oncogenic pathways.

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