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The Cell Cycle Control System01:28

The Cell Cycle Control System

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Related Experiment Video

Updated: May 1, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

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Myc and cell cycle control.

Gabriel Bretones1, M Dolores Delgado1, Javier León1

  • 1Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), CSIC-Universidad de Cantabria-SODERCAN and Departamento de Biología Molecular, Universidad de Cantabria, Santander, Spain.

Biochimica Et Biophysica Acta
|April 8, 2014
PubMed
Summary

The Myc oncogene drives cell proliferation by inducing cell cycle regulators and DNA replication. Understanding Myc

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Myc gene (c-Myc) expression levels correlate with cell proliferation.
  • Myc deregulation is frequent in human cancers.
  • Understanding Myc's role in cell cycle control is crucial for cancer therapy.

Purpose of the Study:

  • To dissect the mechanisms of Myc's role in cell cycle control.
  • To explore Myc-mediated stimulation of cell cycle progression.
  • To identify therapeutic strategies targeting Myc-driven cancers.

Main Methods:

  • Analysis of Myc target genes encoding cell cycle regulators (Cdks, cyclins, E2F).
  • Investigation of Myc's effects on Cdk activating kinase (CAK) and Cdc25 phosphatases.
  • Examination of Myc's antagonism of cell cycle inhibitors (p21, p27) and regulation of DNA replication and mitotic control.
Keywords:
CdkCell cycleCyclinMycProliferationp21p27

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Main Results:

  • Myc induces critical positive cell cycle regulators and hyperactivates cyclin/Cdk complexes.
  • Myc antagonizes cell cycle inhibitors (p21, p27) via transcriptional repression or protein degradation.
  • Myc promotes DNA replication and regulates genes involved in mitotic control.

Conclusions:

  • Myc orchestrates cell cycle progression through multiple transcriptional and post-transcriptional mechanisms.
  • Targeting cyclin-dependent kinases (Cdks) offers a promising synthetic lethality approach for Myc-driven tumors.
  • Knowledge of Myc-dependent cell cycle regulation can guide novel cancer therapeutic development.