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Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

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DHEA, physical exercise and doping.

K Collomp¹, C Buisson², F Lasne²

¹Laboratoire CIAMS, EA 4532, Université Paris Sud - Université Orléans, France; Département des Analyses, Agence Française de Lutte contre le Dopage, Chatenay-Malabry, France.

The Journal of Steroid Biochemistry and Molecular Biology

|April 8, 2014

Summary

This review explores dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) hormone responses to exercise. Saliva measurements offer a non-invasive way to study these crucial steroid hormones in athletes and various populations.

Keywords:

Acute physical exercise Antidoping analysis Chronic physical exercise Ergogenic effects

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Published on: October 17, 2018

Area of Science:

Endocrinology and Exercise Physiology
Sports Science and Anti-Doping

Background:

Dehydroepiandrosterone (DHEA) and its sulfate conjugate (DHEA-S) are key steroid hormones.
Their concentrations during acute and chronic exercise are areas of recent scientific interest.
Salivary measurements provide a non-invasive method for monitoring DHEA/DHEA-S, correlating well with serum levels.

Purpose of the Study:

To review current knowledge on DHEA/DHEA-S responses to exercise.
To examine factors modulating these hormonal responses, including exercise intensity, gender, age, and training status.
To discuss the ergogenic potential of exogenous DHEA administration and associated anti-doping detection methods.

Main Methods:

Review of existing literature on DHEA/DHEA-S concentrations during exercise.
Analysis of modulating factors such as exercise intensity, gender, age, and training.
Examination of ergogenic claims and current anti-doping analytical techniques for DHEA.

Main Results:

DHEA is preferred for acute exercise studies due to its shorter half-life; DHEA-S is preferred for chronic adaptations.
Salivary DHEA/DHEA-S measurements are reliable and non-invasive, suitable for diverse populations and competitive settings.
Factors like exercise intensity, gender, age, and training significantly influence DHEA/DHEA-S responses.

Conclusions:

DHEA and DHEA-S are important biomarkers of physiological adaptation to exercise.
Non-invasive salivary monitoring allows for comprehensive study of these hormones in various contexts.
Understanding DHEA/DHEA-S responses is critical for sports science, anti-doping efforts, and clinical applications.