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Related Experiment Video

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Does oral clonidine premedication decrease bleeding during open rhinoplasty?

Reza Tabrizi1, Hamidreza Eftekharian, Freydoun Pourdanesh

  • 1From the *Department of Maxillofacial Surgery, Shahidbeheshti University of Medical Science, Tehran; †Department of Anesthesiology, Shiraz University of Medical Science, Shiraz; ‡Department of Maxillofacial Surgery, Shahidbeheshti University of Medical Sciences, Tehran; and §Department of Maxillofacial Surgery, Shiraz University of Medical Science, Shiraz, Iran.

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Oral clonidine premedication significantly reduced blood loss during open rhinoplasty. This study found that patients receiving clonidine experienced less bleeding compared to those given a placebo.

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Area of Science:

  • Anesthesiology
  • Plastic Surgery
  • Surgical Hemorrhage Control

Background:

  • Minimizing blood loss in open rhinoplasty is crucial for surgical outcomes and patient safety.
  • Preoperative medications are explored to enhance surgical conditions, including reduced bleeding.

Purpose of the Study:

  • To evaluate the efficacy of oral clonidine premedication in reducing preoperative blood loss during open rhinoplasty.

Main Methods:

  • A uni-blind randomized clinical trial was conducted with two groups: one receiving oral clonidine (0.2 mg) and the other a placebo, 2 hours before general anesthesia.
  • All participants underwent open rhinoplasty without septoplasty, adhering to a standardized anesthetic protocol.
  • Blood loss was measured, and variables such as patient weight, age, sex, and blood pressure were controlled.

Main Results:

  • The clonidine group (n=33) exhibited significantly lower mean blood loss (68.03 ± 22.49 mL) compared to the placebo group (n=33) (132.12 ± 78.53 mL).
  • Statistical analysis confirmed a significant difference in blood loss between the two groups (P < 0.001).

Conclusions:

  • Oral clonidine premedication is an effective strategy for decreasing preoperative bleeding in patients undergoing open rhinoplasty.
  • Clonidine may improve surgical field visualization and potentially reduce complications associated with excessive blood loss.