Related Experiment Videos
Enzyme catalytic concentrations in human plasma after a marathon.
1Institut für Klinische Chemie und Pathobiochemie, Klinikum der Justus-Liebig-Universität, Giessen, FRG.
Clinical Biochemistry
|April 1, 1989
Summary
Marathon running significantly alters key blood enzyme levels. Creatine kinase and other enzymes increased post-race, while others like cholinesterase decreased, with some returning to baseline levels over days.
Area of Science:
- Sports Medicine
- Clinical Chemistry
- Biochemistry
Background:
- Athletic exertion, such as marathon running, can induce physiological stress.
- Understanding biochemical changes in athletes is crucial for monitoring health and performance.
Purpose of the Study:
- To investigate the impact of marathon running on specific serum enzyme activities.
- To analyze the temporal changes in these enzymes following strenuous exercise.
Main Methods:
- Blood samples were collected from 11 male marathon runners before, immediately after, and on three days following the 1986 Berlin Marathon.
- Catalytic concentrations of creatine kinase (CK), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AP), cholinesterase (CHE), amylase (AML), and gamma glutamyltransferase (GGT) were measured.
Main Results:
- Activities of CK, LDH, ALT, AST, and AP significantly increased post-marathon.
- Activities of CHE, AML, and GGT decreased immediately after the marathon.
- Time-course analysis showed elimination of AP and LDH isoenzymes from plasma to pre-race levels.
Conclusions:
- Marathon running causes transient alterations in serum enzyme profiles.
- These changes reflect muscle damage and metabolic shifts associated with endurance exercise.
- Enzyme levels generally normalize within days post-exertion.