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Appendicitis

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Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...

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Appendicitis-I: Introduction

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...

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Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

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Published on: August 24, 2019

Appendiceal skip inflammation and ulcerative colitis.

Sang Hyoung Park¹, Edward V Loftus, Suk-Kyun Yang

¹Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Korea.

Digestive Diseases and Sciences

|April 8, 2014

Summary

This summary is machine-generated.

Inflammation near the appendix, known as appendiceal orifice inflammation (AOI) or peri-appendiceal red patch (PARP), is linked to distal ulcerative colitis (UC). While its prognostic role is debated, AOI/PARP may associate with appendiceal neoplasms.

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Area of Science:

Gastroenterology
Colorectal Surgery
Pathology

Background:

Appendiceal orifice inflammation (AOI) or peri-appendiceal red patch (PARP) is increasingly recognized in patients with distal ulcerative colitis (UC).
Epidemiological studies suggest a correlation between appendectomy and a reduced incidence of UC.
The precise clinical significance of AOI/PARP as a potential
skip lesion
in UC requires further elucidation.

Purpose of the Study:

To review and summarize existing literature on AOI/PARP in the context of UC.
To explore the association between AOI/PARP and UC disease characteristics.
To investigate the potential implications of AOI/PARP in UC prognosis and appendiceal neoplasia.

Main Methods:

Literature review synthesizing findings from histologic examination of colectomy specimens and colonoscopy reports.
Analysis of the association between AOI/PARP and UC disease extent, severity, and clinical course.
Examination of case reports linking AOI/PARP to appendiceal neoplasms and therapeutic outcomes of appendectomy in refractory UC.

Main Results:

AOI/PARP is more frequently observed in distal, mild UC compared to extensive, severe disease.
The prognostic impact of AOI/PARP on UC remission, relapse, and proximal disease extension remains controversial but appears minimal.
Case reports suggest a potential link between AOI/PARP and appendiceal neoplasms, including cystadenoma and adenocarcinoma.

Conclusions:

AOI/PARP is a recognized finding in distal UC, often associated with milder disease phenotypes.
While its prognostic significance in UC is limited, AOI/PARP may warrant consideration for appendiceal neoplasia.
Further research is needed to clarify the etiologic and pathogenic roles of appendiceal inflammation in UC and the therapeutic efficacy of appendectomy.