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Nontraditional applications in clinical pathology.

Holly L Jordan1, Thomas C Register2, Niraj K Tripathi3

  • 1GlaxoSmithKline, Research Triangle Park, North Carolina, USA holly.l.jordan@gsk.com.

Toxicologic Pathology
|April 8, 2014
PubMed
Summary

This review explores nonroutine clinical pathology applications in drug development, moving beyond standard hematology and chemistry in common lab animals. It highlights advanced techniques for bone markers, special populations, and novel analyzer uses.

Keywords:
Advia®Wistar ratbone biomarkers.bone markersclinical pathologyguinea pighamsterhematologyjuvenileminipigpregnantrabbittransgenic

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Area of Science:

  • Preclinical toxicology
  • Drug development
  • Clinical pathology

Background:

  • Traditional reviews focus on routine clinical pathology in standard toxicology species (rats, mice, dogs, nonhuman primates).
  • Established endpoints include hematology, clinical chemistry, coagulation, and urinalysis.
  • There is a need to explore non-traditional applications in drug discovery.

Purpose of the Study:

  • To present and discuss contemporary, nonroutine applications of clinical pathology endpoints in drug development.
  • To summarize key topics from a continuing education course at the Society of Toxicologic Pathology Symposium.
  • To highlight advanced methodologies beyond standard toxicological assessments.

Main Methods:

  • Expert presentations on specialized clinical pathology topics.
  • Discussion of bone turnover markers in laboratory animals.
  • Review of clinical pathology in pregnant, growing, and nonroutine animal species.
  • Exploration of unique applications of specific hematology analyzers (Siemens Advia®).

Main Results:

  • Contemporary examples of nonroutine clinical pathology applications were presented.
  • Specific focus areas included bone turnover markers, special animal models, and advanced hematology analysis.
  • The content was derived from a continuing education course at a major toxicology pathology symposium.

Conclusions:

  • Nonroutine clinical pathology endpoints offer valuable insights in drug development.
  • Advanced applications extend beyond standard assessments in common toxicology species.
  • Further exploration of these methods can enhance preclinical toxicology and drug discovery.