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Area of Science:

  • Orthopedic Surgery
  • Infectious Diseases
  • Biomedical Engineering

Background:

  • Periprosthetic joint infection (PJI) following total knee arthroplasty (TKA) presents significant clinical and economic challenges.
  • Existing evidence regarding PJI prevention, pathophysiology, diagnosis, and treatment is often insufficient or conflicting.
  • There is a critical need for updated clinical guidance to manage PJI effectively.

Purpose of the Study:

  • To review and synthesize the latest published literature on periprosthetic joint infection of the knee.
  • To provide an updated perspective on the management of PJI, addressing controversial aspects.
  • To consolidate current knowledge for clinicians managing infectious complications after TKA.

Main Methods:

  • Comprehensive literature search of recently published studies on PJI of the knee.
  • Analysis and synthesis of evidence related to prevention, pathophysiology, diagnosis, and treatment strategies.
  • Focus on identifying areas of consensus and controversy in current PJI management.

Main Results:

  • Significant advancements and ongoing debates exist in PJI prevention and pathophysiology.
  • Diagnostic criteria and treatment modalities for PJI continue to evolve.
  • Recent literature highlights emerging strategies and challenges in managing knee PJI.

Conclusions:

  • Updated understanding of PJI is crucial for optimizing patient outcomes after TKA.
  • Further research is needed to resolve existing controversies in PJI management.
  • This review provides a contemporary overview to guide clinical decision-making for knee PJI.