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Related Concept Videos

Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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Immune Surveillance by NK Cells and Phagocytes01:25

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Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
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Cells of the Adaptive Immune Response01:23

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Overview
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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Updated: May 1, 2026

Generation of Natural Killer Cells from Human Expanded Potential Stem Cells
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Natural killer cell in the developing life.

Yen-Chang Lee, Syh-Jae Lin

    Journal of Perinatal Medicine
    |April 8, 2014
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    Summary
    This summary is machine-generated.

    Natural killer (NK) cells are crucial for pregnancy and neonatal immunity. This review details their roles in implantation, placentation, immune tolerance, and infant immune defense, highlighting cell interactions.

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    A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro
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    Area of Science:

    • Immunology
    • Developmental Biology
    • Reproductive Immunology

    Background:

    • Natural killer (NK) cells are key innate immune cells with diverse functions.
    • Their roles vary significantly across different tissues and developmental stages.
    • NK cells are implicated in early life processes, including pregnancy and neonatal development.

    Purpose of the Study:

    • To review recent advancements on the role of NK cells during pregnancy.
    • To examine NK cell involvement in neonatal immune defense.
    • To discuss interactions between NK cells and other immune cells throughout development.

    Main Methods:

    • Literature review of recent scientific advances.
    • Synthesis of research on NK cell functions in pregnancy and neonates.
    • Analysis of immune cell interactions in developmental contexts.

    Main Results:

    • NK cells play critical roles in successful implantation and placentation.
    • They are essential for maintaining immune tolerance during pregnancy.
    • NK cells contribute significantly to the immune defense mechanisms of newborns.

    Conclusions:

    • NK cells are vital for reproductive success and healthy pregnancy outcomes.
    • Understanding NK cell dynamics is crucial for neonatal immunity.
    • Further research into NK cell interactions can inform therapeutic strategies.