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Related Concept Videos

Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
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Absolute MR thermometry using nanocarriers.

Roel Deckers1, Sara M Sprinkhuizen, Bart J Crielaard

  • 1Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands.

Contrast Media & Molecular Imaging
|April 8, 2014
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Researchers developed a novel magnetic resonance imaging (MRI) method for hyperthermia-mediated drug delivery. Nanocarrier materials act as precise nano-thermometers for accurate temperature mapping during treatment.

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MR thermometrydrug deliveryliposomesmicellespolymers

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Medical Imaging

Background:

  • Accurate temperature monitoring is essential for effective hyperthermia cancer therapy.
  • Current methods for temperature mapping during drug delivery are limited.
  • Nanocarrier systems offer potential for targeted drug delivery and theranostics.

Purpose of the Study:

  • To develop and validate a novel MRI-based temperature mapping technique for hyperthermia treatments.
  • To utilize drug delivery systems as integrated nano-thermometers for absolute MR thermometry.
  • To assess the temperature-independent reference capabilities of specific nanocarrier materials.

Main Methods:

  • Investigated temperature-dependent chemical shift differences between water protons and nanocarrier protons (polyethylene glycol and N-(2-hydroxypropyl)-methacrylamide).
  • Utilized multigradient echo MRI sequences for time-resolved temperature mapping.
  • Validated the method using PEGylated liposomes in situ for absolute MR thermometry.

Main Results:

  • Demonstrated that polyethylene glycol (PEG) and N-(2-hydroxypropyl)-methacrylamide (HPMA) exhibit temperature-independent proton resonances, serving as reliable reference frequencies.
  • Established a linear relationship between water proton resonance frequency and temperature, independent of pH and salt conditions.
  • Successfully achieved accurate, time-resolved temperature mapping using PEGylated liposomes with MR imaging.

Conclusions:

  • Nanocarrier materials can function as accurate and precise nano-thermometers for absolute MR thermometry.
  • This approach enhances the safety and efficacy of hyperthermia-mediated drug delivery.
  • The developed method offers a versatile tool for advanced cancer theranostics.