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Inhibition of cAMP increase by an anti-allergic agent, NCO-650, during histamine release
1Department of Pharmacology, Tokushima Bunri University, Japan.
International Archives of Allergy and Applied Immunology
|January 1, 1989
Abstract:
Antigen and concanavalin A (Con A) induced an increase in cAMP and histamine release from rat peritoneal mast cells. In a dose-dependent manner, the compound, NCO-650, significantly inhibited both the initial and secondary increases in cAMP stimulated by antigen, anti-IgE and Con A in rat peritoneal mast cells. IC50 values of NCO-650 for cAMP increase stimulated by antigen, anti-IgE and Con A were 3.8, 3.4 and 2.8 microM, respectively.