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Propionylcarnitine and methionine concentrations in newborns with hypospadias

Andrzej Kowal1, Dariusz Mydlak1, Mariusz Ołtarzewski2

  • 1Department of Pediatric Surgery.

Central European Journal of Urology
|April 8, 2014
PubMed

Insights

Increased propionylcarnitine, a marker for vitamin B12 deficiency, was found in newborns with hypospadias. This suggests a link between low vitamin B12 levels and hypospadias risk.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Nutritional Science

Background:

  • Maternal diet may influence hypospadias risk.
  • Elevated propionylcarnitine (C3) indicates vitamin B12 deficiency.
  • Hypospadias is a common congenital anomaly in male newborns.

Purpose of the Study:

  • To investigate the association between elevated propionylcarnitine and methionine levels in newborns and hypospadias.
  • To explore the potential role of vitamin B12 deficiency in hypospadias etiology.

Main Methods:

  • Retrospective study of 41 newborns with hypospadias and 90 controls.
  • Tandem mass spectrometry used to measure whole blood propionylcarnitine and methionine concentrations.

Main Results:

  • Newborns with hypospadias showed significantly higher mean propionylcarnitine levels (p = 0.026).
  • Methionine levels were insignificantly lower in the hypospadias group compared to controls.

Conclusions:

  • An association exists between increased propionylcarnitine, indicating vitamin B12 deficiency, and hypospadias.
  • This finding suggests a potential link between maternal vitamin B12 status and hypospadias development.
Abstract

Keywords:
MS/MShypospadiasmethioninepropionylcarnitinevitamin B12

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