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Updated: May 1, 2026
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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Lymphatic filariasis disseminating to the upper extremity
Catherine Maldjian1, Vineet Khanna1, Bevan Tandon2
1Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213-2582, USA.
Case Reports in Radiology
|April 8, 2014
Summary
Magnetic resonance imaging (MRI) reveals unique findings in active lymphatic filariasis, an infection causing lymphedema. These new imaging insights may aid in diagnosing this debilitating parasitic disease.
Area of Science:
- Medical Imaging
- Parasitology
- Infectious Diseases
Background:
- Lymphatic filariasis is a major global cause of acquired lymphedema, affecting over 100 million people.
- Caused primarily by Wuchereria bancrofti, it is a leading cause of permanent disability.
- Diagnostic challenges exist due to limited MRI data in pathologically confirmed active infections.
Purpose of the Study:
- To report the first pathological correlation of MRI findings in active extremity filariasis.
- To describe novel MRI characteristics associated with active filarial infection.
- To enhance diagnostic capabilities for filariasis.
Main Methods:
- Retrospective analysis of MRI scans in active filariasis cases.
- Pathological correlation of imaging findings.
- Description of specific MRI signal characteristics and tissue appearances.
Main Results:
- MRI demonstrated an enhancing, infiltrative, mass-like appearance with vascular encasement.
- Low signal strands within T2-hyperintense dilated lymphatic channels were observed.
- These findings may represent live adult worms and their cuticles.
Conclusions:
- Novel MRI findings, including low signal strands in dilated lymphatics, may indicate active filariasis.
- These specific imaging features could prompt early diagnosis and treatment.
- Pathological correlation with MRI enhances understanding of filarial infections.
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