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Related Experiment Videos

Pulmonary corpora amylacea in sheep.

X Lin1, M R Alley, B W Manktelow

  • 1Department of Veterinary Pathology, Massey University, Palmerston North, New Zealand.

Journal of Comparative Pathology
|April 1, 1989
PubMed
Summary

Pulmonary corpora amylacea (PCA) were identified in lambs with chronic pneumonia. These structures, found in alveoli, may result from airway obstruction and stagnant exudate.

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Area of Science:

  • Veterinary Pathology
  • Pulmonary Research
  • Sheep Medicine

Background:

  • Pulmonary corpora amylacea (PCA) are rare microscopic findings in lung tissue.
  • Their formation and significance in ovine respiratory disease are not well understood.
  • Chronic non-progressive pneumonia is a recognized condition in lambs.

Purpose of the Study:

  • To investigate the presence, morphology, and composition of pulmonary corpora amylacea in lambs with chronic non-progressive pneumonia.
  • To compare ovine PCA with human counterparts.
  • To postulate the pathogenesis of ovine PCA in relation to pneumonia.

Main Methods:

  • Histopathological examination of lung tissues from lambs with chronic non-progressive pneumonia.
  • Staining techniques to determine the biochemical composition of PCA.
  • Electron microscopy for ultrastructural analysis.
  • Comparison with existing literature on human PCA.

Main Results:

  • Pulmonary corpora amylacea (PCA) were present in 36% of affected lambs.
  • PCA were spheroidal/ovoid, concentrically lamellar structures located in alveoli.
  • Staining indicated deoxyribonucleoproteins, glycoproteins, and ribonucleoproteins; electron microscopy revealed granular material.
  • Morphological and staining differences were noted between ovine and human PCA, possibly age-related.

Conclusions:

  • Ovine PCA are associated with chronic non-progressive pneumonia.
  • It is hypothesized that PCA formation is indirectly caused by bronchiolar stenosis and exudate stagnation.
  • Further research is needed to fully elucidate the role and development of PCA in ovine lung disease.

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