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Polymer composites containing gated mesoporous materials for on-command controlled release.

Carolina Acosta1, Edgar Pérez-Esteve, Carlos A Fuenmayor

  • 1Grupo de Investigación e Innovación alimentaria (CUINA), Universidad Politécnica de Valencia , 46022 Valencia, Spain.

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Summary
This summary is machine-generated.

Novel hybrid nanomaterials with gated silica particles enable controlled release of garlic extract. These materials offer on-demand delivery, responding to pH changes or enzymatic activity for various applications.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Developing advanced drug delivery systems is crucial for targeted and controlled release of bioactive compounds.
  • Mesoporous silica particles offer high surface area and tunable pore structures for encapsulation.
  • Polyamidic nanofibrous membranes provide a versatile scaffold for composite material fabrication.

Purpose of the Study:

  • To develop novel hybrid composite nanomaterials for the encapsulation and on-command delivery of garlic extracts.
  • To investigate the controlled release mechanisms of garlic extract from functionalized mesoporous silica particles integrated into nanofibrous membranes.
  • To evaluate the potential of these nanomaterials in pharmacology, medicine, and engineering.

Main Methods:

  • Fabrication of polyamidic nanofibrous membranes incorporating gated silica mesoporous particles (MCM-41).
  • Functionalization of silica particles with linear polyamines (P1) and hydrolyzed starch (P2) to act as molecular gates.
  • Characterization of composite materials (M1, M2) using FE-SEM.
  • Evaluation of garlic extract release using cyclic voltammetry under varying pH and enzymatic conditions.

Main Results:

  • FE-SEM confirmed successful incorporation of silica particles onto nylon-6 nanofibers.
  • pH-responsive release: P1 and M1 materials showed a closed gate at acidic pH and an open gate at neutral pH.
  • Enzyme-responsive release: P2 and M2 materials exhibited negligible release without pancreatin but significant release in its presence.
  • Demonstrated controlled and on-demand delivery of entrapped garlic extract.

Conclusions:

  • Developed novel hybrid composite nanomaterials with gated silica mesoporous particles for controlled delivery.
  • Demonstrated tunable release mechanisms based on pH and enzymatic triggers.
  • These materials offer a homogeneous, easy-to-handle system with bioactive-protective features for potential applications in various fields.