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Dose requirements of remifentanil for intubation in nonparalyzed Chinese children

Hua-Cheng Liu1, Wei-Ke Tao, Rui-Feng Zeng

  • 1Department of Anesthesiology, the Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Paediatric Anaesthesia
|April 9, 2014
PubMed

Insights

This study determined the effective doses of remifentanil for tracheal intubation in nonparalyzed Chinese children. The effective dose 50 (ED50) and effective dose 95 (ED95) of remifentanil combined with propofol were found to be lower than previously reported.

Area of Science:

  • Anesthesiology
  • Pediatric Anesthesia
  • Pharmacology

Background:

  • Determining effective doses of anesthetic agents is crucial for pediatric procedural safety.
  • Remifentanil and propofol are commonly used for induction of general anesthesia in children.
  • Optimizing intubation conditions in nonparalyzed children requires precise dosing of anesthetic agents.

Purpose of the Study:

  • To determine the median effective dose (ED50) and the 95% effective dose (ED95) of remifentanil for tracheal intubation.
  • To evaluate the efficacy of remifentanil in combination with propofol for intubation in nonparalyzed Chinese children.
  • To compare the determined remifentanil doses with previously reported values.

Main Methods:

  • A cohort of 47 ASA Class I children (aged 4-11 years) received a fixed dose of propofol (2.5 mg·kg(-1)).
  • Remifentanil was administered intravenously with dose titration based on intubation conditions.
  • Hemodynamic parameters and pulse oximetry were monitored throughout the procedure.

Main Results:

  • The ED50 of remifentanil for satisfactory intubation was 2.30 μg·kg(-1) (95% CI: 2.28-2.31).
  • The ED95 of remifentanil for satisfactory intubation was 2.75 μg·kg(-1) (95% CI: 2.59-3.35).
  • These effective doses were lower than those reported in previous studies.

Conclusions:

  • The ED50 and ED95 of remifentanil for adequate intubation in nonparalyzed Chinese children are lower than previously documented.
  • The combination of propofol and remifentanil provides effective intubating conditions in this pediatric population.
  • These findings suggest potential ethnic or demographic differences in anesthetic requirements.
Abstract

Keywords:
ED50ED95childrenendotracheal intubationpropofolremifentanil

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