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Effect of intracameral use of dexamethasone on corneal endothelial cells
Ahmad Zeeshan Jamil1, Arslan Ahmed2, Khurram Azam Mirza2
1Department of Ophthalmology, Rashid Latif Medical College, Ferozpur Road, Lahore.
Objective:
To evaluate the effect of intracameral dexamethasone on corneal endothelium.
Study Design:
Quasi experimental study.
Place And Duration Of Study:
Layton Rehmatulla Benevolent Trust Eye Hospital, Lahore, from May 2011 to January 2012.
Methodology:
Study subjects were adults of either gender with senile cataract who underwent phacoemulsification. They were divided in two groups, each had 110 patients. Group-A received subconjunctival injection of dexamethasone (2 mg/0.5 ml) at the end of surgery while group-B received intracameral injection of dexamethasone (0.4 mg/0.1 ml) at the end of surgery. Endothelial cell count was performed by specular microscopy pre-operatively and postoperatively at first week, first month and three months. Outcome measures included changes in endothelial cell count. Results were compared using t-test for means.
Results:
There were 55 (50%) males and 55 (50%) females in group-A and 44 (40%) males and 66 (60%) females in group-B. In group-A, there were 66 (60%) right and 44 (40%) left eyes while group-B had 62 (56.36%) right and 48 (43.63%) left eyes. Mean age in group-A was 55.17 ± 5.93 years and 54.87 ± 5.55 years in group-B. Mean phacoemulsification time in group-A was 1.92 ± 0.63 minutes and 1.82 ± 0.54 minutes in group-B. After 3 months, in group-A, there was 7.55 ± 1.19% endothelial cell loss while in group-B, there was 7.63 ± 1.10% endothelial cell loss. The difference between the two groups was not statistically significant (p=0.614).
Conclusion:
Use of intracameral dexamethasone at the end of cataract surgery is safe for corneal endothelium.
