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Updated: May 1, 2026
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Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
Published on: April 3, 2011
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Strain background determines lymphoma incidence in Atm knockout mice
Paula C Genik1, Helle Bielefeldt-Ohmann2, Xianan Liu3
1Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO.
Neoplasia (New York, N.Y.)
|April 9, 2014
Summary
Genetic variations influence leukemia and lymphoma development in ataxia-telangiectasia (A-T) patients. Modifier genes impact disease onset and type, suggesting a complex genetic basis for cancer susceptibility in A-T.
Area of Science:
- Genetics
- Oncology
- Immunology
Background:
- Ataxia-telangiectasia (A-T) is a rare genetic disorder.
- 10-30% of A-T patients develop leukemias or lymphomas.
- Cancer development in A-T shows significant variation in onset and type.
Purpose of the Study:
- Investigate the role of modifier genes in A-T-associated lymphomagenesis.
- Determine if genetic background influences leukemia/lymphoma susceptibility in Atm-deficient mice.
Main Methods:
- Created Atm knockout mice on various inbred murine strains.
- Analyzed thymic lymphoma incidence and latency across different genetic backgrounds.
- Examined sequence alterations in arising lymphomas.
Main Results:
- Observed significant differences in lymphoma incidence and latency among Atm(-/-) mice on distinct genetic backgrounds.
- Lymphomas exhibited similar patterns of genetic alterations.
- Identified specific mouse strains influencing lymphomagenesis.
Conclusions:
- Genetic background plays a crucial role in modulating lymphomagenesis in Atm-deficient individuals.
- Modifier genes contribute to the variable cancer susceptibility seen in A-T.
- The characterized Atm congenic mouse strains are valuable for identifying these modifier genes.
