Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

8.3K
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
8.3K
Erythropoiesis01:14

Erythropoiesis

5.7K
Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
5.7K
Erythropoiesis01:14

Erythropoiesis

4.0K
4.0K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.7K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.7K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

3.9K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
3.9K
Hemoglobin01:24

Hemoglobin

8.8K
Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
8.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of gypsum waste on MSW and WTE ash for material recovery and syngas enhancement.

Waste management (New York, N.Y.)·2025
Same author

Effect of gypsum waste inclusion on syngas production during CO<sub>2</sub>-assisted gasification of waste tires.

Waste management (New York, N.Y.)·2023
Same author

Thermal deformation of gold nanostructures and its influence on surface plasmon resonance sensing.

Nanoscale advances·2022
Same author

Long-Term Culture of Nephron Progenitor Cells Ex Vivo.

Methods in molecular biology (Clifton, N.J.)·2019
Same author

Comparison of miRNA quantitation by Nanostring in serum and plasma samples.

PloS one·2017
Same author

Planar photonic crystal based multifunctional sensors: erratum.

Applied optics·2017

Related Experiment Video

Updated: May 1, 2026

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes
08:53

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Published on: January 10, 2025

1.1K

Does erythropoietin cause hemoglobin variability--is it 'normal'?

Ashwani K Gupta1, Waseem David1

  • 1Department of Nephrology, University of Florida-Jacksonville, Jacksonville, Florida, United States of America.

Plos One
|April 9, 2014
PubMed
Summary

Hemoglobin variability in dialysis patients is higher than in healthy adults, even without erythropoiesis stimulating agents (ESA). Age significantly influences this variability, suggesting intrinsic factors are key determinants.

More Related Videos

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
09:12

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

14.8K
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

11.2K

Related Experiment Videos

Last Updated: May 1, 2026

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes
08:53

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Published on: January 10, 2025

1.1K
Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
09:12

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

14.8K
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

11.2K

Area of Science:

  • Nephrology
  • Hematology
  • Internal Medicine

Background:

  • Hemoglobin variability (Hb-var) in chronic kidney disease (CKD) patients is often attributed to erythropoiesis stimulating agents (ESA).
  • Elevated Hb-var in dialysis patients has been linked to increased mortality.
  • The role of intrinsic factors in Hb-var independent of ESA remains unclear.

Purpose of the Study:

  • To investigate the existence and extent of Hb-var independent of ESA administration in peritoneal dialysis (PD) patients.
  • To compare Hb-var in PD patients with and without ESA treatment to healthy adults.
  • To identify determinants of Hb-var in PD patients.

Main Methods:

  • Analysis of data from 1571 PD patients (116 not requiring ESA) and healthy adults from Scripps-Kaiser and NHANES III databases.
  • Comparison of Hb-var between PD patients requiring ESA and those not requiring ESA.
  • Statistical analysis to identify predictors of ESA need and Hb-var determinants.

Main Results:

  • PD patients exhibited significantly increased Hb-var independent of ESA treatment (0.99 gm/dL vs. 1.17 gm/dL, p<0.001).
  • White race and male sex predicted the need for ESA therapy.
  • Age was a significant determinant of Hb-var in the ESA-treated group, with younger PD patients showing 50% higher Hb-var than young healthy adults.

Conclusions:

  • Exogenous ESA administration does not fully explain Hb-var in PD patients and may exacerbate it.
  • Intrinsic factors, particularly age, appear to be major determinants of Hb-var in PD patients.
  • Hb-var in elderly PD patients resembles anemia of aging, suggesting age-related erythropoiesis changes.