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NASH: the tribulations of conducting NASH trials
1Saint Louis University, 3635 Vista Ave, Saint Louis, MO 63105, USA.
Nature Reviews. Gastroenterology & Hepatology
|April 9, 2014
Abstract:
Designing clinical trials for the treatment of NASH is challenging. The pathogenesis of this disease is poorly understood and is probably multifactorial. A trial of a phosphodiesterase-4 inhibitor produced negative results, despite promising preclinical data. Examining why this trial failed might help us design better trials of treatments for NASH in the future.
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