Related Experiment Video

Updated: May 1, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

34.6K

Intersection of cardiovascular disease and kidney disease: atrial fibrillation

Nisha Bansal1, Chi-yuan Hsu, Alan S Go

  • 1aKidney Research Institute, University of Washington, Seattle, Washington bUniversity of California, San Francisco, San Francisco, California cKaiser Permanente Northern California, Oakland, California, USA.

Current Opinion in Nephrology and Hypertension
|April 9, 2014
PubMed

Insights

Atrial fibrillation is common in kidney disease patients. More research is needed on its mechanisms and treatments for those with chronic kidney disease (CKD) and end-stage renal disease (ESRD).

Area of Science:

  • Nephrology
  • Cardiology
  • Internal Medicine

Background:

  • Atrial fibrillation (AF) is the most prevalent sustained arrhythmia in patients with kidney disease.
  • The association between AF and kidney disease, including chronic kidney disease (CKD) and end-stage renal disease (ESRD), presents a significant clinical challenge.

Purpose of the Study:

  • To delineate the substantial burden of atrial fibrillation in patients with CKD and ESRD.
  • To explore potential mechanisms underlying the increased prevalence and impact of AF in kidney disease.
  • To review the clinical consequences and current treatment strategies for AF in this high-risk population.

Main Methods:

  • This is a review article, synthesizing existing literature on atrial fibrillation in kidney disease.
  • Analysis of recent studies examining the clinical impact, mechanisms, and therapeutic options for AF in CKD and ESRD patients.

Main Results:

  • The clinical multiorgan impact of AF in CKD and ESRD patients is substantial.
  • Limited data exists on the efficacy and safety of novel oral anticoagulants (NOACs) in advanced CKD and ESRD populations.
  • AF represents a significant comorbidity with serious prognostic implications for individuals with kidney disease.

Conclusions:

  • Atrial fibrillation is a critical comorbidity in patients with CKD and ESRD, carrying significant prognostic weight.
  • Further research is imperative to elucidate the mechanisms driving the disproportionate burden of AF in kidney disease.
  • Tailored treatment strategies for AF are needed for this specific, high-risk patient cohort.
Abstract

More Related Videos

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.2K
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

2.8K

Related Concept Videos

Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.2K
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.6K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
3.4K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.9K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
559