Related Experiment Video

Updated: May 1, 2026

Automating Tumor Implantation in Zebrafish Larvae for Cancer Research and Medicine
06:14

Automating Tumor Implantation in Zebrafish Larvae for Cancer Research and Medicine

Published on: September 19, 2025

1.2K

Implementing precision medicine initiatives in the clinic: a new paradigm in drug development

Antoine Hollebecque1, Christophe Massard, Jean-Charles Soria

  • 1aDrug Development Department (DITEP: Département d'Innovations Thérapeutiques et Essais Précoces) bInserm Unit U981, Gustave Roussy Cancer Campus, Villejuif cFaculté du Kremlin Bicêtre, Université Paris Sud, France.

Current Opinion in Oncology
|April 9, 2014
PubMed
Abstract

Insights

Genomic screening identifies molecular targets for advanced cancer, improving precision medicine. High-throughput analysis in daily practice aids targeted therapy selection and accelerates drug development.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Advances in genome sequencing reveal molecular alterations in advanced cancers.
  • These alterations present potential therapeutic targets for precision medicine.

Purpose of the Study:

  • Review methods for molecular screening in cancer.
  • Examine the success of precision medicine programs.
  • Discuss challenges and future perspectives.

Main Methods:

  • High-throughput technologies for disease stratification.
  • Analysis of molecular screening methods.
  • Review of precision medicine program outcomes.

Main Results:

  • High-throughput technologies enable stratification of diseases into molecular subtypes.
  • Predictive biomarkers are crucial for drug development in early clinical trials.
  • Ongoing prospective trials show promising results.

Conclusions:

  • Genomic characterization is critical for selecting targeted therapies.
  • High-throughput analysis is feasible for daily practice.
  • Molecular screening enriches early-phase clinical trials.

More Related Videos

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

14.0K
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.6K

Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
121
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

1.5K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
159
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.7K
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
253