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Updated: May 1, 2026
Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
Published on: March 17, 2023
Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen
Yusuke Yoshioka1, Nobuyoshi Kosaka2, Yuki Konishi3
11] Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan [2] Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo 162-8480, Japan [3] Research Fellow of the Japan Society for the Promotion of Science (JSPS), Chiyoda-Ku, Tokyo 102-0083, Japan.
Researchers developed a new method to detect cancer-derived extracellular vesicles (EVs) in blood. This sensitive liquid biopsy technique uses CD147 antigen for early colorectal cancer detection, aiding diagnosis and therapy.
Area of Science:
- Oncology
- Biotechnology
- Translational Medicine
Background:
- Cancer cells release extracellular vesicles (EVs) into circulation, showing potential as biomarkers.
- Identifying and quantifying EVs in clinical samples for cancer diagnosis is currently challenging.
Purpose of the Study:
- To develop a sensitive and rapid analytical technique for profiling circulating EVs directly from blood samples of colorectal cancer patients.
- To enable the detection of cancer-derived EVs without a purification step.
Main Methods:
- Utilized a novel technique to capture EVs using two types of antibodies.
- Employed photosensitizer-beads for detecting captured EVs.
- Focused on the antigen CD147, which is present in cancer-linked EVs.
Main Results:
- Successfully profiled circulating EVs directly from blood samples of colorectal cancer patients.
- Demonstrated sensitive detection of cancer-derived EVs without prior purification.
- Showcased the utility of CD147-embedded EVs for colorectal cancer detection.
Conclusions:
- The described liquid biopsy technique offers sensitive detection of disease-specific circulating EVs.
- This approach provides new perspectives for translational medicine in cancer diagnosis and therapy.
