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Updated: May 1, 2026

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Role of Cell Division Autoantigen 1 (CDA1) in Cell Proliferation and Fibrosis

Ban-Hock Toh1, Yugang Tu2, Zemin Cao3

  • 1Autoimmunity Laboratory, Centre for Inflammatory Diseases, Department of Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria 3168, Australia. ban-hock.toh@monash.edu.

Genes
|April 9, 2014
PubMed

Insights

Cell Division Autoantigen 1 (CDA1) shows anti-proliferative and pro-fibrotic effects, impacting cell growth and extracellular matrix production. This discovery highlights CDA1 as a potential therapeutic target for tumors and fibrotic vascular diseases like atherosclerosis.

Area of Science:

  • Molecular biology
  • Immunology
  • Cellular biology

Background:

  • Cell Division Autoantigen 1 (CDA1) was identified using serum from a patient with Discoid Lupus Erythematosus.
  • CDA1, encoded by the TSPYL2 gene on the X chromosome, exhibits properties similar to TGF-β.

Purpose of the Study:

  • To investigate the molecular mechanisms and therapeutic potential of CDA1.
  • To elucidate the role of CDA1 in cell proliferation, DNA damage response, and fibrotic processes.

Main Methods:

  • Screening of a human expression library.
  • Analysis of CDA1's effects on cell growth pathways (p53, pERK1/2, p21).
  • Investigation of CDA1's interaction with TGF-β signaling in extracellular matrix production.

Main Results:

  • CDA1 inhibits cell growth via p53, pERK1/2, and p21 pathways.
  • CDA1 promotes fibrosis through cross-talk with TGF-β, upregulating extracellular matrix proteins.
  • CDA1 plays a significant role in atherosclerosis associated with diabetes.

Conclusions:

  • CDA1 possesses dual anti-proliferative and pro-fibrotic properties.
  • CDA1 is implicated in tumorigenesis and DNA damage response.
  • CDA1 represents a promising molecular target for treating cancers, vascular fibrosis, atherosclerosis, and related fibrotic disorders.

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