Autophagy and cancer
Related Experiment Video
Updated: May 1, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
Published on: January 31, 2025
Francesca Aredia1, Luis Miguel Guamán Ortiz2, Vincenzo Giansanti3
1IGM-CNR, Via Abbiategrasso 207, Pavia 27100, Italy. francesca.aredia@gmail.com.
Abstract:
Autophagy is a housekeeping survival mechanism with a protective function against stress conditions. However, when stress severity or duration increases, it may promote cell death. Paradoxically, autophagy favors cancer development, since cancer cells could enhance their proliferation potential (thus becoming able to resist anticancer therapy) thanks to the energetic supply provided by organelle degradation typically driven by autophagy following a stepwise pathway. The main actors of the autophagic machinery as well as the features shared with apoptosis will be described. Special attention will be paid to the effects of autophagy manipulation.
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