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The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress

Arthur Marivin1, Jean Berthelet2, Stéphanie Plenchette3

  • 1Institut National de la Santé et de la Recherche Médicale (Inserm), UMR866, Dijon F-21079, France. arthurmarivin@gmail.com.

Cells
|April 9, 2014
PubMed

Insights

Inhibitor of Apoptosis (IAPs) proteins protect cells from stress and damage. This review explores their role in cellular adaptation, survival, and disease.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cells face constant endogenous and exogenous injuries.
  • Cells activate "guardian molecules" to cope with stress.
  • Inhibitor of Apoptosis (IAPs) proteins are key pro-survival factors.

Purpose of the Study:

  • To review the anti-apoptotic and survival functions of IAPs.
  • To discuss the role of IAPs in the adaptive response to cellular stress.
  • To explore IAP involvement in human physiology and diseases.

Main Methods:

  • Literature review of IAP functions.
  • Analysis of IAP induction by cellular stress (hypoxia, ER stress, DNA damage).
  • Discussion of IAP roles in homeostasis and disease.

Main Results:

  • IAPs exhibit anti-apoptotic and pro-survival properties.
  • IAP expression is induced by various cellular stresses.
  • IAPs confer tolerance to cellular stress, aiding survival and repair.

Conclusions:

  • IAPs are crucial for cellular adaptation and survival under stress.
  • Dysregulation of IAPs is linked to the breakdown of cellular homeostasis and disease.
  • Understanding IAPs offers insights into human physiology and pathology.

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