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Related Concept Videos

Mass Spectrometry: Overview01:19

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Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass spectrometry is to generate ions from the analyte molecule and measure these ion abundances against their molecular mass. One common type of ionization, known as electron ionization or EI, bombards the analyte molecules in the gas phase with high-energy electron beams. The electron beams displace an electron from the molecule and leave behind a...
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Related Experiment Video

Updated: May 1, 2026

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS
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LC-MS-based metabolomics: an update.

Zhong-Ze Fang1, Frank J Gonzalez

  • 1Laboratory of Metabolism, Center for Cancer Research, National Institutes of Health, Bethesda, MD, 20892, USA.

Archives of Toxicology
|April 9, 2014
PubMed
Summary
This summary is machine-generated.

Liquid chromatography-mass spectrometry (LC-MS) metabolomics aids xenobiotic metabolism, toxicity, and disease research. Advancements are needed in sample preparation and databases for broader applications.

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Toxicology

Background:

  • Metabolomics, particularly LC-MS, offers powerful insights into biological systems.
  • Integration with techniques like stable isotope tracing enhances metabolomic studies.
  • Understanding xenobiotic metabolism and disease is crucial for public health.

Purpose of the Study:

  • To review recent applications of LC-MS metabolomics in xenobiotic metabolism and toxicity.
  • To highlight metabolomics' role in understanding disease pathogenesis and therapeutic targets.
  • To discuss limitations and future directions for LC-MS metabolomics.

Main Methods:

  • Review of recent literature on LC-MS metabolomics applications.
  • Focus on studies involving xenobiotic metabolism, drug toxicity, and disease.
  • Integration of metabolomics with other advanced research technologies.

Main Results:

  • Metabolomics has elucidated the metabolism of noscapine and mechanisms of liver toxicities from various drugs.
  • LC-MS-based studies provide insights into inflammatory bowel disease, alcohol-induced liver disease, and non-alcoholic steatohepatitis.
  • Metabolomics aids in identifying therapeutic targets, such as within the farnesoid X receptor signaling pathway.

Conclusions:

  • LC-MS metabolomics is a valuable tool for studying xenobiotic metabolism, toxicity, and disease.
  • Further development in sample preparation, databases, and metabolite standards is essential for advancing metabolomic research.
  • Overcoming current limitations will broaden the scope and impact of metabolomic studies in various scientific fields.