Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bionic Magnetic Nanorobots Combined with AI-Assisted Microscopic Imaging for Argonaute-Powered Multiplexed Foodborne Pathogens Detection.

Journal of agricultural and food chemistry·2026
Same author

A Multimodal Strategy for Enhancing Minimally Invasive Ablation of Lung Tumor.

Annals of biomedical engineering·2026
Same author

Systematic investigation of a Fraxinus mandshurica seed-derived iridoid glucoside fraction as a novel functional ingredient with anti-diabetic potential.

Fitoterapia·2026
Same author

Beyond silos: An integrated sustainability hierarchy framework.

iScience·2026
Same author

The Caspase-1/GSDMD/PXN/VCAM-1 Cascade Mediates Cerebral Ischemia-Reperfusion Injury.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

CAND1 drives intestinal ischemia/reperfusion injury via SCF<sup>FBXO6</sup>-PKM2-mediated mitochondrial fission and apoptosis.

Free radical biology & medicine·2026

Related Experiment Video

Updated: May 1, 2026

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration
05:05

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration

Published on: November 23, 2019

7.6K

2D/4D marker-free tumor tracking using 4D CBCT as the reference image.

Mengjiao Wang1, Gregory C Sharp, Simon Rit

  • 1Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, People's Republic of China. Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.

Physics in Medicine and Biology
|April 9, 2014
PubMed
Summary

This study presents a novel marker-free method for tracking tumor motion during radiotherapy using 2D/4D cone beam computed tomography (CBCT) matching. The technique accurately tracks diaphragm position as a surrogate for real-time tumor motion, improving treatment precision.

More Related Videos

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

15.2K
Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning
10:25

Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning

Published on: April 12, 2024

2.3K

Related Experiment Videos

Last Updated: May 1, 2026

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration
05:05

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration

Published on: November 23, 2019

7.6K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

15.2K
Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning
10:25

Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning

Published on: April 12, 2024

2.3K

Area of Science:

  • Medical Physics
  • Radiotherapy Technology
  • Image-Guided Interventions

Background:

  • Respiration-induced tumor motion poses a significant challenge in image-guided radiotherapy, potentially reducing treatment accuracy.
  • Current methods for tracking tumor motion often rely on implanted markers, which can be invasive and introduce complications.

Purpose of the Study:

  • To develop and validate a novel, marker-free 2D/4D matching method for real-time tumor motion tracking in image-guided radiotherapy.
  • To assess the accuracy of tracking diaphragm position as a surrogate for tumor motion.

Main Methods:

  • Reconstruction of 3D and phase-binned 4D cone beam computed tomography (CBCT) volumes.
  • Combination of 4DCBCT and streak-free 3DCBCT to enhance digitally reconstructed radiograph (DRR) quality.
  • Conversion of 2D/4D matching to 2D/2D matching using diaphragm position as a surrogate for tumor tracking.

Main Results:

  • The developed method achieved a diaphragm matching accuracy of 1.88 ± 1.35 mm and a 2D tumor tracking accuracy of 2.13 ± 1.26 mm in the isocenter plane.
  • Validation was performed on datasets for lung and liver applications with varying acquisition times.
  • The method demonstrated feasibility for real-time, marker-free tumor motion tracking.

Conclusions:

  • The implemented 2D/4D matching technique provides accurate and reliable marker-free tumor motion tracking in image-guided radiotherapy.
  • Utilizing diaphragm position as a surrogate for tumor motion simplifies the tracking process and enhances clinical applicability.
  • This method holds promise for improving the precision and safety of radiotherapy by accounting for respiratory motion.