Low testosterone is associated with disability in men with multiple sclerosis.

Area of Science:

• Neurology
• Endocrinology
• Immunology

Background:

• Gonadal steroids, such as testosterone, may influence the progression of multiple sclerosis (MS).
• Hypogonadism, a condition of low sex hormone production, is being investigated for its role in MS.
• Understanding hormonal influences is crucial for managing MS in men.

Purpose of the Study:

• To determine the prevalence of hypogonadism in men diagnosed with MS.
• To explore the relationship between hypogonadism and clinical indicators of MS severity.
• To investigate potential associations between testosterone levels and disease progression.

Main Methods:

• A cohort of 96 male patients with relapsing-remitting MS (RRMS) or clinically-isolated syndrome (CIS) were analyzed.
• Hormone levels, including total testosterone, were measured from stored blood samples.
• Clinical data, such as Expanded Disability Status Scale (EDSS) and Symbol Digit Modalities Test (SDMT) scores, were collected longitudinally.

Main Results:

• 39% of men with MS exhibited hypogonadism (total testosterone < 288 ng/dL).
• Low testosterone levels were negatively correlated with body mass index (BMI) and leptin.
• Lower baseline testosterone levels were associated with increased disability (EDSS) and faster cognitive decline (SDMT).

Conclusions:

• Hypogonadotropic hypogonadism may affect men with MS.
• Low testosterone levels in men with MS are linked to poorer clinical outcomes.
• Testosterone's potential neuroprotective effects in MS warrant further research.