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Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

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Related Experiment Video

Updated: May 1, 2026

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Remarkable findings in suicidal hanging

Lucia Tattoli¹, Claas T Buschmann, Michael Tsokos

¹Institute of Legal Medicine, University of Bari, P.zza G. Cesare, 11, 70124, Bari, Italy, luciatattoli@libero.it.

Forensic Science, Medicine, and Pathology

|April 9, 2014

Summary

No abstract available in PubMed .

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