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Related Concept Videos

Larynx01:21

Larynx

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The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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The Hyoid Bone01:12

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The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
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Pharynx01:20

Pharynx

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The pharynx, a tubular structure framed by skeletal muscle and lined with mucous membrane, extends continuously from the nasal cavities. It is segmented into three major areas: the nasopharynx, oropharynx, and laryngopharynx.
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The nasopharynx, bordered by the conchae of the nasal cavity, serves exclusively as an air conduit. In its superior region, the pharyngeal tonsils or adenoids are located. These tonsils are clusters of lymphoid reticular tissue akin to a lymph node. The precise...
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Anatomy of Respiratory System I: Upper Respiratory Tract01:29

Anatomy of Respiratory System I: Upper Respiratory Tract

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The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
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Trachea01:22

Trachea

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The trachea, commonly known as the windpipe, is a vital part of the human respiratory system. It serves as a passageway for air to travel between the larynx and the bronchi, allowing oxygen to reach the lungs. Let's explore its anatomical features, dimensions, layers of the tracheal wall, associated muscles, and the functions of its parts.
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Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles
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How the operated larynx ages.

E Crosetti1, P Garofalo2, C Bosio3

  • 1ENT Dept., Martini Hospital, Torino, Italy;

Acta Otorhinolaryngologica Italica : Organo Ufficiale Della Societa Italiana Di Otorinolaringologia E Chirurgia Cervico-Facciale
|April 9, 2014
PubMed
Summary

Open partial laryngectomy (HOPL) can impair laryngeal function, but long-term outcomes show manageable dysphagia and dysphonia. Aspiration pneumonia (AP) is more common early post-surgery and decreases over time.

Keywords:
AspirationElderlyOpen partial laryngectomySupracricoid partial laryngectomySupraglottic partial laryngectomySupratracheal partial laryngectomy

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Area of Science:

  • Otolaryngology
  • Geriatric Medicine
  • Surgical Oncology

Background:

  • Open partial laryngectomy (HOPL) is a common surgical procedure for laryngeal cancer.
  • Post-operative laryngeal function often deteriorates over time, impacting swallowing and voice.
  • Long-term functional outcomes after HOPL in elderly patients require further investigation.

Purpose of the Study:

  • To evaluate laryngeal functional outcomes at least 10 years after open partial laryngectomy (HOPL).
  • To assess the incidence of aspiration pneumonia (AP) and its association with dysphagia.
  • To analyze the impact of surgical intervention type and extent on dysphagia, dysphonia, and voice handicap.

Main Methods:

  • Retrospective cohort study of 80 elderly patients who underwent HOPL.
  • Objective and subjective assessments of laryngeal function, including swallowing and voice.
  • Analysis of aspiration pneumonia (AP) incidence and its correlation with dysphagia severity.

Main Results:

  • Eight patients (10%) experienced aspiration pneumonia (AP), with four having recurrent episodes.
  • A significant association was found between AP and the severity of dysphagia (p < 0.001).
  • Dysphagia was more pronounced than in age-matched controls but less than anticipated; voice handicap correlated with glottic resection extent.

Conclusions:

  • Laryngeal function remains impaired after HOPL, but does not significantly affect long-term quality of life.
  • Aspiration pneumonia (AP) incidence is higher in the early post-operative period and diminishes over subsequent years.
  • The type and extent of surgical intervention significantly influence dysphagia and voice outcomes post-HOPL.