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Topical delivery of vitamin d3: a randomized controlled pilot study
Mir Sadat-Ali1, Dalal A Bubshait1, Haifa A Al-Turki1
1College of Medicine, University of Dammam, King Fahd Hospital of the University, AlKhobar, Saudi Arabia.
International Journal of Biomedical Science : IJBS
|April 9, 2014
Summary
Transdermal vitamin D3 delivery is feasible, significantly increasing 25-hydroxyvitamin D levels in participants using a novel cream. This study demonstrates a safe and effective method for treating vitamin D deficiency.
Area of Science:
- Dermatology
- Endocrinology
- Nutritional Science
Background:
- Vitamin D deficiency is a widespread health concern.
- Oral supplementation can be challenging for some individuals.
- Exploring alternative delivery methods for vitamin D is crucial.
Purpose of the Study:
- To assess the feasibility of transdermal vitamin D3 delivery.
- To evaluate the efficacy of a novel topical vitamin D3 formulation.
- To determine if the dermal route can effectively increase serum 25-hydroxyvitamin D levels.
Main Methods:
- A randomized controlled study involving 48 female medical students.
- Participants applied either a vitamin D3-aloe vera cream (Top-D) or an aloe vera gel control for 3 months.
- Serum 25-hydroxyvitamin D3 (25OHD) levels were measured pre- and post-treatment.
Main Results:
- The vitamin D3 cream group showed a significant increase in mean 25OHD levels from 12.05 ng/mL to 37.95 ng/mL (P=0.001).
- The control group experienced no significant change in 25OHD levels (11.4 ng/mL to 10.58 ng/mL).
- No adverse effects were reported, indicating a safe application.
Conclusions:
- Transdermal delivery of vitamin D3 is a safe and effective method.
- Topical vitamin D3 application can successfully replete serum 25OHD levels.
- This route offers a promising alternative for managing vitamin D deficiency.
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