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Related Experiment Videos

Substance P involved in mental disorders.

K Takeuchi1, M Uematsu, M Ofuji

  • 1Department of Neurology and Psychiatry, Gifu University School of Medicine, Japan.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Substance P (SP) may play a role in schizophrenia. Antipsychotic drugs reduce SP levels, but SP

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Substance P (SP) is a neuropeptide implicated in various brain functions.
  • The striatonigral pathway is a key SP pathway in the brain.
  • SP in the substantia nigra influences the nigro-striatal dopamine system.

Purpose of the Study:

  • To review the involvement of substance P (SP) in the pathophysiology of mental disorders, particularly schizophrenia.
  • To examine the relationship between SP levels, antipsychotic medication, and schizophrenia.

Main Methods:

  • Review of existing literature on substance P, dopamine systems, and schizophrenia.
  • Analysis of studies on SP concentrations in post-mortem brain samples of schizophrenic patients.
  • Consideration of the effects of SP antagonists like baclofen.

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Main Results:

  • Antipsychotic drug administration is associated with decreased SP concentration in the substantia nigra.
  • Elevated SP concentrations have been observed in specific brain regions of schizophrenic patients.
  • The therapeutic effects of baclofen (an SP antagonist) in schizophrenia remain unclear.

Conclusions:

  • Substance P (SP) is potentially involved in the neurobiological mechanisms underlying schizophrenia.
  • Further research is needed to elucidate the precise role of SP in schizophrenia and its potential as a therapeutic target.